Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer

Figure 3 Classification of resolvins. Resolvins are biosynthesized from ω-3 polyunsaturated fatty acids (PUFA) by specific enzymes including lipoxygenase (LOX). Resolvin E (RvE) is endogenously produced from eicosapentaenoic acid (EPA) during endothelial cell-leukocyte interaction. RvE1 and RvE2 are biosynthesized through two different pathways via cytochrome P450-driven oxygenation of EPA or via aspirin-acetylated cyclooxygenase 2 (COX-2). RvE3 is generated via the 12/15-LOX pathway. In addition, resolvin D (RvD) is biosynthesized from docosahexaenoic acid (DHA) via 15/5-LOX within vascular endothelial cells. To date, six members of this family has been identified RvD1-6. Also, RvD is also biosynthesized via aspirin-acetylated COX-2, and we call aspirin triggered RvD (AT-RvD).