Case Report
Copyright ©The Author(s) 2016.
World J Clin Cases. Mar 16, 2016; 4(3): 81-87
Published online Mar 16, 2016. doi: 10.12998/wjcc.v4.i3.81
Table 2 Classification of cryoglobulins and laboratory findings[4,18]
Cryoglobulin typeContentRelated diseasesLaboratory findings
Type IMonoclonal immunoglobulins (IgG, IgM or IgA) or Bence Jones protein/monoclonal free light chainsMultiple MyelomaPrecipitation within 24 h Hyperviscosity
Waldenstrom Macroglobulinemia
Lymphoproliferative disease related monoclonal gammopathy
Light chain disease
Type II (mixed)Monoclonal immunoglobulins (IgG, IgM or IgA) and polyclonal immunoglobulins (usually IgG)HCVPrecipitation within 7 d HCV positivity Decreased C3 Decreased C4 Decreased CH50 Increased autoantibodies such as ANA, ENA, AMA
Essential cryoglobulinemia
Sjogren’s syndrome
Rheumatoid arthritis
Chronic lymphocytic leukemia
Type III (mixed)Polyclonal immunoglobulinsEssential cryoglobulinemia
Sjogren’s syndrome
Systemic lupus erythematosus
Viral infections (HBV, CMV, EBV, HIV)
Endocarditis
Biliary cirrhosis