Paclitaxel-associated reticulate hyperpigmentation: Report and review of chemotherapy-induced reticulate hyperpigmentation

Table 2 Adverse drug reaction probability scale^1,2,3,4

Question	PA	PS
Are there previous conclusive reports on this reaction?	Yes	1
Answer score: Yes = +1; No = 0
Did the adverse event appear after the suspected drug was administered?	Yes	2
Answer score: Yes = +2; No = -1
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	Yes	1
Answer score: Yes = +1; No = 0
Did the adverse reaction reappear when the drug was readministered?	Yes	2
Answer score: Yes = +2; No = -1
Are there alternative causes (other than the drug) that could on their own have caused the reaction?	No	2
Answer score: Yes = -1; No = +2
Did the reaction reappear when a placebo was given?	DNK	0
Answer score: Yes = -1; No = +1
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	DNK	0
Answer score: Yes = +1; No = 0
Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?	DNK	0
Answer score: Yes = +1; No = 0
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	DNK	0
Answer score: Yes = +1; No = 0
Was the adverse event confirmed by any objective evidence?	Yes	1
Answer score: Yes = +1; No = 0
Total score		9

¹An answer is provided for all questions (PA) and a determination of score is provided (PS) to assess the adverse drug reaction; ²An answer of “Do not know” = 0 score; ³From the total score, the adverse drug reaction is assigned a probability category: Definite (greater than or equal to 9), probable (5 to 8), possible (1 to 4), doubtful (less than or equal to 0); ⁴Drug = paclitaxel. DNK: Do not know; PA: Patient answer; PS: Patient score.