Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferative verrucous leukoplakia

Table 2 Clinicopathological data of 15 patients with proliferative verrucous leukoplakia included in the study

Case	Anatomiclocation	Histopathologicfindings	Treatment	Follow-up time (yr)	Status
1	1a, 3a, 3b, 4, 5, 6b	Epithelial dysplasia (3a, 6b) OSCC (3b)	Surgery	11	Alive
2	2, 3b, 5a, 6a, 8, 9	Epithelial dysplasia (2, 9) OSCC (2, 8)	Surgery	5	Alive
3	2, 3b, 4, 10	Acanthosis/hiperkeratosis (2, 10) Epithelial dysplasia (2)	-	10	Alive
4	2, 5a, 6a, 7a	Acanthosis/hyperkera tosis (2) Epithelial dysplasia (2, 5a)	-	20	Alive
5	2, 5a, 5b, 6b	Acanthosis/dysplasia (6b)	-	2	Alive
6	2, 3a, 4, 5a, 9	Epithelial dysplasia (3a)	-	1	Alive
7	2, 3b	-	-	2	Alive
8	2, 6a, 7b	Acanthosis/hyperkera tosis (7b) Epithelial dysplasia (7b)	-	4	Alive
9	1b, 2, 3a, 3b, 4, 6a, 6b	Epithelial dysplasia (1b, 2)	-	1	Alive
10	2, 3b, 6a	Epithelial dysplasia (3b)	-	3	Alive
11	2, 3a, 3b, 4, 5a, 6b, 8	Epithelial dysplasia (8) Verrucous carcinoma (5a) OSCC (4)	Surgery + RT	6	Alive
12	2, 4, 5b, 6b, 8	Acanthosis/hiperkeratosis (5b) Epithelial dysplasia (2)	-	3	Alive
13	2, 3b	Epithelial dysplasia (3b) OSCC (3b)	-	3	Alive
14	1a, 1b, 2, 3a, 3b, 4, 6a, 6b	Epithelial atrophy/ hyperkeratosis (3b)	-	1	Alive
15	1a, 1b, 2, 3a, 3b, 5a, 5b, 6a, 6b, 8	Epithelial dysplasia (5a, 5b)	-	10	Alive

1a: Inferior labial mucosa; 1b: Superior labial mucosa; 2: Buccal mucosa; 3a: Tongue (ventral); 3b: Tongue (lateral border); 4: Floor of mouth; 5a: Inferior alveolar ridge; 5b: Superior alveolar ridge; 6a: Inferior fórnix; 6b: Superior fornix; 7a: Inferior gengiva; 7b: Superior gengiva; 8: Hard palate; 9: Soft palate; 10: Tonsil pillar. OSCC: Oral squamous cell carcinoma.