Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis

Figure 1 The outcome and activity level of CD11a knockout mice in polymicrobial sepsis. A: The outcome of polymicrobial sepsis in wild-type (WT) and CD11a knockout mice. Statistical significance was evaluated using Log-rank test (P = 0.0024). The activity level of WT and CD11a mice following polymicrobial sepsis is shown; B: Activity was numbered from 0 to 5 based on responsiveness and appetite as described in Methods. Statistical analysis was performed using two-way analysis of variance with Bonferroni post hoc analysis. In both (A) and (B), ^bP < 0.01, respectively. KO: Knockout.