Role of genetic polymorphisms in hepatitis C virus chronic infection

Table 4 Role of other single nucleotide polymorphisms in hepatitis C virus infection

Ref.	Gene	SNPs/haplotypes	Important results
	CRS (7 genes):
Huang et al[145]	AZIN1	rs62522600	The Cirrhosis Risk Score was evaluated both in retrospective and prospective studies and appeared to be a useful predictor of fibrosis progression in patients with mild chronic hepatitis C, even in special populations (i.e., liver transplant recipients or HIV-HCV coinfected patients)
Marcolongo et al[146]	TLR4	rs4986791
Trépo et al[148]	TRMP5	rs886277
Curto et al[147]	AP3S2	rs2290351
do O et al[150]	B008027	rs4290029
Fernández-Rodríguez et al[149]	AQP2	rs2878771
	STXBP5	rs17740066
Nattermann et al[152]	IL-6	rs1800795	The CC genotype was associated with lower plasma levels of IL-6 and seemed to correlate with higher SVR rate and lower grading and staging, although the data from the literature are discordant, probably due to the heterogeneity of the study populations (i.e., different virological and clinical characteristics, HIV-coinfection, etc.)
Yee et al[151]
Falleti et al[153]
Cussigh et al[154]
Khakoo et al[156]	KIR-HLA	KIR2DL3/HLAC1	The association between KIR2DL3 and HLAC1 appeared to be related to both a spontaneous and treatment-induced resolution of HCV infection
Knapp et al[157]
Huang et al[145]	IFNγ	rs2069707	The C764G polymorphism seemed to be associated with a higher SVR rate and a more frequent spontaneous viral clearance
Hellier et al[163]	CCR5	CCR5Δ32	The CCR5Δ32 deletion, which was associated with resistance to HIV infection, seemed to correlate with lower spontaneous clearance of HCV and milder inflammation and fibrosis, although the data from the literature are discordant
Nattermann et al[164]
Goulding et al[165]
Coppola et al[158]	CNR2	rs35761398	The CB2-65 QQ genotype was associated with the PNALT status in chronic HCV infection, but also with a higher HAI
Coppola et al[159]

PNALT: Persistently normal alanine-amino-transferase; HAI: Histological activity index; SVR: Sustained viral response; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; IL- 6: Interleukin-6; SNPs: Single nucleotide polymorphisms.