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Copyright ©The Author(s) 2015.
World J Clin Cases. Apr 16, 2015; 3(4): 330-337
Published online Apr 16, 2015. doi: 10.12998/wjcc.v3.i4.330
Figure 3
Figure 3 Coagulation cascade. Factors Xa and IIa (thrombin) are the principal targets for the new oral anticoagulants, while factors II, VII, IX, X, and protein C and S are decreased by the vitamin K antagonist, warfarin. Warfarin’s effect on the factor VIIa/TF complex is a possible cause of the increased intracranial bleeding seen in warfarin compared to the newer targeted agents.