Probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir

Table 2 Time course of critical laboratory values

	Before antiviral therapy	Day 14 of treatment	Day 21 of the initiation of treatment (day 3 after discontinuation of the treatment)	Day 35 of the initiation of treatment (day 17 after discontinuation of the treatment)
Hematology
WBC (μL)	5000	12130	7800	5950
Neutrophils (%)		82	35	47
Lymphocytes (%)		10	26	43
Monocytes (%)		6	6	7
Eosinophils (%)		1	32	3
Plt (μL)	111000	79000	130000	115000
Blood chemistry
Albumin (g/dL)	4.1	3.3	3.4	4.2
T-Bil (mg/dL)	0.5	1.9	0.4	0.5
D-Bil (mg/dL)	0	0.7	0.1	0.1
AST (IU/L)	57	15	17	28
ALT (IU/L)	57	22	18	23
ChE (IU/L)	311	257	204	276
T. Chol (mg/dL)	170	126	140	179
BUN (mg/dL)	13	28	6	16
Cre (mg/dL)	0.7	1.4	0.6	0.8
CRP (mg/dL)	0.1	3.5	0.6	0
Blood coagulation
PT (%)	102	66.4	74.5	95.5
PT-INR	1.01	1.22	1.16	1.04

WBC: White blood cell; Plt: Platelets; PT: Prothrombin time; T-Bil: Total bilirubin; T. Chol: Total cholesterol; CRP: C-reactive protein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ChE: Cholinesterase; BUN: Blood urea nitrogen; D-Bil: Direct bilirubin; INR: International normalized ratio.