Cost-effectiveness in Clostridium difficile treatment decision-making

Table 1 Summary of the most relevant therapeutic issues in Clostridium difficile infection

Level	Issues
Patient level	Recurrence of CDI is a serious and difficult-to-treat problem[26]
	Patient groups at high risk of recurrence or those for whom the impact of recurrence would be most dramatic include those with multiple comorbidities, who are immunocompromised, who are receiving certain concomitant antibiotics[26, who have had CDI previously, who are renally impaired, who are aged 65 yr or over, patients awaiting further treatment (for example chemotherapy) or rehabilitation (for example after cerebrovascular event)
Population level	The rate of person-to-person transmission of C. difficile is a complicating problem
	The risk for development of vancomycin-resistant enterococci or other antibiotic induced resistant bacteria, although it is not a major issue in daily practice

CDI: Clostridium difficile infection.