Therapeutic strategies for targeting the ovarian tumor stroma

Figure 1 Therapeutic strategies to target the tumor microenvironment. Shown are examples of different strategies and agents that inhibit the regulation of a specific type of stromal cell or its functional properties. Several of these agents are in clinical use, whereas others are at different stages of clinical development. VEGF: Vascular endothelial growth factors; TAMs: Tumor-associated macrophages; CAFs: Cancer-associated fibroblasts; TGF-β: Transforming growth factor-β; FAP: Fibroblast activation protein; CCL2: chemokine (C-C motif) ligand 2; VEGFR: Vascular endothelial growth factor receptor.