Promising new treatment targets in patients with fibrosing lung disorders

doi:10.12998/wjcc.v2.i11.668

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Nov 16, 2014; 2(11): 668-675
Published online Nov 16, 2014. doi: 10.12998/wjcc.v2.i11.668

Table 3 Ongoing clinical studies in idiopathic pulmonary fibrosis patients

Target	Potential molecular target	Ongoing clinical study
Signals from other cells	Interleukin 13	Lebrikizumab NCT01872689
Autocrine signals	Connective tissue growth factor	Tralokinumab NCT02036580
		FG-3019 NCT01890265
Cell surface	Lysophosphatidic acid receptor Lysyl oxidase LOXL2 CD20 Androgen receptor	Lysophosphatic acid receptor antagonist-NCT01766817 Simtuzumab NCT01769196 Rituximab NCT01969409 Nandrolone decanoate NCT02055456
Plasma membrane-cytosol interface	Phosphoinositol kinase PI3K	Phosphoinositol kinase PI3K inhibitor NCT01725139
Cytosol signal transducers	Αvβ6 integrin	STX-100 NCT01371305
Nucleus		None
Stem cells		Autologous adipose-derived adult stem cells NCT02135380
		Autologous mesenchymal bone marrow-derived stem cells NCT01919827
		Allogenic human mesenchymal stem cells NCT02013700

Citation: Sterclova M, Vasakova M. Promising new treatment targets in patients with fibrosing lung disorders. World J Clin Cases 2014; 2(11): 668-675
URL: https://www.wjgnet.com/2307-8960/full/v2/i11/668.htm
DOI: https://dx.doi.org/10.12998/wjcc.v2.i11.668