Squamous cell carcinoma of the scrotum: A look beyond the chimneystacks

Table 4 Case series with epidemiology, management and outcomes of scrotal squamous cell carcinoma published after 2000

Ref.	n	Design	Cohort characteristics	Summary
Stern et al[17], 2002	17	Prospective multi-institutional cohort study	892 men first treated with PUVA	Dose-dependent increase in the risk of genital tumors in men treated with PUVA
Seabra et al[19], 2007	6	Retrospective single institution	Age: 52 (31-89) Race: Ca: 2; Bl: 2; Oth: 1; Unknown: 1 Staging: LC: 4, RL: 1, DD: 1	4/6 WLE; 1/6 WLE + SLNB; 1/6 was unresectable: 1 developed LN metastasis and was treated with chemo/radiation Patient with unresectable disease and was treated with chemotherapy and subsequently died
Wright et al[2], 2008	151	SEER (1973-2002)	Age: 682 Race: Ca 117 (77.5); Bl 24 (15.9); Oth 10 (6.6)	SCC had the worse survival compared to other histological subtypes
Verhoeven et al[1], 2010	53	NCR (1989-2006)	Age: 56.5 Staging: Stg 0: 1 (1.9), Stg 1: 22 (41.5), Stg 2: 18 (34), Stg 3: 2 (3.8), Stg 4: 0, Unk: 10 (18.9)	SCC had the worse survival compared to other histological subtypes: 1 yr relative survival 93% 3 yr relative survival 80% 5 yr relative survival 77%
Johnson et al[16], 2013	269	SEER (1973-2006)	Age: 65.42± 14.9 Race: Ca 206 (76.6%), Bl 43 (16.0%), As 12 (4.5%), Hi 18 (6.7%), Oth 8 (3.0%) Staging: LC 205 (76.2%), RL 54 (20.1%), DD 10 (3.7%)	The median OS for patients with SCC was 115 (95%CI: 97-133) mo
Matoso et al[18], 2014	29	Retrospective multi-institutional	Age: 55 (30-74) Race: Ca 19 (65.5%), Bl 10 (34.5%) Follow up: 37 mo	25/29 WLE; 1/29 WLE + LND; 3/29 imiquimod post WLE: 13 (45%) with1 margins required re-excision1 3/29 local recurrence: 2 WLE; 1 WLE/RT 3 /29 with lymphadenopathy lost to follow-up

¹Positive;

²Mean. As: Asian; Bl: Black; Ca: Caucasians; DD: Distant disease; Hi: Hispanics; LC: Local disease; NCR: Netherlands Cancer Registry; OS: Overall survival; Oth: Other; PUVA: Psoralens and ultraviolet A radiation; RL: Regional lymph node; SCC: Squamous cell carcinoma; SEER: Surveillance, Epidemiology and end results; SLNB: Sentinel lymph node biopsy; Stg: Stage; WLE: Wide local excision.