Evolution of endovascular mechanical thrombectomy for acute ischemic stroke

Table 2 Comparison of randomized trials of endovascular thrombectomy for AIS

Trial	Treatment arms	n	Revascularizationa (%)	Good outcomebc (%)	Symptomatic ICH (%)	Mortalityb (%)
SWIFT	Merci Retriever	55	67	33	11	38
	Solitaire FR	58	89	58	2	17
TREVO 2	Merci Retriever	90	60	22	2	24
	Trevo Pro	88	86	40	4	33
SYNTHESISd	IVT	181	NR	35	6	6
	EVT	181	NR	30	6	8
IMS III	IVT	222	NR	39	6	22
	IVT + EVT	434	e	41	6	19
MR Rescue	Penumbral, IVT	34	93	26	6	21
	Penumbral, EVT	34	67	21	9	18
	Nonpenumbral, IVT	20	78	10	0	30
	Nonpenumbral, EVT	30	77	17	0	20

^aDefined as TIMI or TICI grade ≥ 2a, final revascularization rate including rescue therapies;

^bAssessed at 90 d unless otherwise specified;

^cDefined as mRS ≤ 2 unless otherwise specified;

^dThis study used mRS ≤ 1 as the primary clinical efficacy endpoint and assessed mortality at day 7 ± 2;

^eReported as 65%, 81%, 70% and 77% for ICA, M1, single M2 and multiple M2 occlusions, respectively; statistically significant (P < 0.05); SWIFT: SOLITAIRE™ with the intention for thrombectomy; TREVO 2: Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke; AIS: Acute ischemic stroke; IMS: Interventional Management of Stroke; IVT: Intravenous thrombolysis; ICH: Intracerebral hemorrhage; TIMI: Thrombolysis in Myocardial Infarction; TICI: Thrombolysis in Cerebral Ischemia; mRS: Modified Rankin Score.