Transient extreme insulin resistance in a critically ill patient: A case report

Table 2 Case reports of critically ill patients with extreme insulin resistance requiring an insulin infusion rate > 100 units/hour

Ref.	Age/sex	Diagnoses	Highest glucose level (mg/dL)	Target glucose range (mg/dL)	Peak insulin infusion rate (U/hour)	Time to target range (from peak insulin infusion rate)	Duration of insulin infusion	Hypoglycemia	Outcome
Naghmi and Kaboor[4], 1988	70/F	DKA	> 1000	< 250	200	9 hours1	NA	Yes	NA
	40/M	DKA	> 600	< 250	400	5 hours1	NA	Yes	NA
	40/M	DKA	> 500	< 250	1000	6 hours1	NA	Yes	NA
	20/M	DKA	> 600	< 250	200	9 hours1	NA	No	NA
Yokoyama et al[5], 1992	65/M	DKA	1241	< 300	10000	6 hours1	23 hours	Yes	Survived
Surani et al[8], 2012	62/F	Septic shock	> 400	< 200	832	5 hours	17 hours	No	NA
Oo et al[9], 2013	60/M	DKA and AMI	847	NA	120	NA	NA	NA	Survived
Illuri et al[6], 2016	64/F	Sepsis	430	180-200	142	16 hours	6 days	No	Deceased
July et al[10], 2017	68/M	AMI, cardiac arrest	434	140-180	280	24 hours1	5 days	No	Deceased
The present case	68/F	Cardiac arrest, sepsis	850	150-200	960	8 hours	11 days	Yes	Deceased

¹Obtained from figures or tables of the reference article.

AMI: Acute myocardial infarction; DKA: Diabetic ketoacidosis; F: Female; M: Male; NA: Not available.