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Copyright ©The Author(s) 2025.
World J Clin Cases. Jun 16, 2025; 13(17): 99924
Published online Jun 16, 2025. doi: 10.12998/wjcc.v13.i17.99924
Figure 5
Figure 5 Crosstalk between host and microbes: Impact on metabolism. The intestinal barrier is composed of different factors such as epithelial cells, a mucus layer, and antimicrobial peptides produced by host cells. The inner mucus layer and the antimicrobial peptides help segregate microbes from the epithelium. Moreover, specific microbes such as Akkermansia muciniphila improve gut barrier function and mucus layer thickness. During high-fat diet feeding and low fibers intake, the gut microbiota composition is different, inflammatory components translocate into the blood via the altered gut barrier function. Citation: Cani PD, Everard A. Talking microbes: When gut bacteria interact with diet and host organs. Mol Nutr Food Res 2016; 60: 58-66. Copyright © Authors 2015. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.