Epithelioid angiosarcoma of the cervical spine: A case report

Table 1 Summary of all 11 spinal epithelioid angiosarcoma cases

Ref.	Age	Sex	Underlying disease	Initial presentation	Primary location	Spine location	Metastasis	Operation	Chemotherapy	Radiotherapy	Outcome
Ghanem et al[8]	54	Male	DM; HTN	Acute back pain and intermittent claudication	Abdominal Aorta	T-L VB	Lung	Resection of Abdominal aorta lesion with aorta repair and angioplasty of right renal artery	Ifosamide, vincristin, etoposid, carboplatin and epirubicin	Local radiation therapy	DOD (17 months)
Deshpande et al[2]	76	Female	Unknown	Unknown	Right Iliac bone and L4 VB	L4 VB	No	Biopsy	No	Palliative radiation	DOD (7 weeks)
Sanchez-Mejia et al[9]	25	Female	No	Weakness, fatigue, and low back pain	S1 VB	S1 VB	Retroperitoneal lymphadenopathy	Sacral laminectomy with resection of tumor	Doxorubicin and ifosfamide	600 cGy of external-beam radiotherapy to sacrum and retroperitoneum	AWD (3 months)
Marthya et al[3]	65	Female	No	Progressive pain over mid-thoracic spine for 3 months	T4 VB and posterior 1/3 of left 4th rib	T4 VB	No	En bloc resection of left 4th rib and decompression of T4 VB	No	3000 cGy direct on field in 10 fractions	NED (2 years)
Ponce et al[10]	27	Male	Unknown	Back pain	T9 VB	T9 VB	Unknown	Thoracoscopic biopsy of T9 VB	No	Postoperative palliative radiotherapy	AWD (43 months)
Chen et al[7]	62	Female	Unknown	Unknown	Femur, Thoracic VB	Thoracic VB	No	Amputation of Femur	No	Yes	DOD (10 months)
Chen et al[7]	53	Male	Unknown	Unknown	Sacrum	Sacrum	No	Radical resection of tumor	No	No	NED (1.5 months)
Lang et al[4]	76	Male	No	Progressive pain over mid-lumbar spine for 5 months	L4 VB	L4 VB	No	L4 laminectomy and L4 VB biopsy	No	No	AWD (6 months)
Swaika et al[11]	49	Female	No	Weight loss, early satiety, nausea, and vomiting for 2 months	Liver, Spleen, Lumbar VB, and right Iliac bone	Lumbar VB	Unknown	Liver biopsy; Iliac bone marrow biopsy	Unknown	Unknown	Unknown
Lemus et al[5]	69	Male	Unknown	Bilateral upper and lower limbs weakness for 2 months	Extramedullary tumor at C7 level	C7	Unknown	C6-7 laminectomy with near-total resection of tumor	No	No	AWD (Unknown)
Our case	63	Male	NPC	Progressive neck drop for 1 month	C6 VB	C6 VB	Lung	C4-7 laminectomy with TPS, C5-6 corpectomy	No	Local radiation therapy for one time	DOD (5 weeks)

AWD: Alive with disease; DM: Diabetes mellitus; DOD: Dead of disease; HTN: Hypertension; NED: No Evidence of disease; VB: Vertebral body; NPC: Nasopharyngeal carcinoma.