Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

doi:10.12998/wjcc.v13.i16.102866

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Jun 6, 2025 (publication date) through Feb 13, 2025

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2025; 13(16): 102866
Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.102866

Table 6 Multivariate logistic analyses between pharmacokinetics and nephrotoxicity

Variables	OR	95%CI	Wald χ²	P value
Intercept	0.2826	0.026-2.565	1.0970	0.2727
Sex	0.8383	0.255-2.805	0.2919	0.7704
Age	1.1870	0.449-3.148	0.3484	0.7275
Weight	1.1540	0.403-3.393	0.2666	0.7898
Main etiologies of ICU cases	1.1600	0.338-3.700	0.2468	0.8051
Comorbidities	1.0740	0.247-5.781	0.0913	0.9272
Infectious site	0.6946	0.395-1.164	1.3400	0.1803
Daily dose	2.5480	0.502-17.650	1.0620	0.2882
C_min	2.9900	1.003-10.470	1.8600	0.0429
AUC_0-24	1.0810	0.151-5.831	0.0872	0.9305
AUC_0-24/MIC	0.8763	0.258-2.906	0.2160	0.8290
APACHE II score	0.6485	0.212-1.960	0.7714	0.4404
Mechanical ventilation	0.5025	0.156-1.592	1.1730	0.2407

APACHE: Acute physiological chronic health evaluation; AUC: Area under the curve; CI: Confidence interval; C_min: Trough concentration; ICU: Intensive care unit; MIC: Minimum inhibitory concentration; OR: Odds ratio.

Citation: Guo T, Du LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. World J Clin Cases 2025; 13(16): 102866
URL: https://www.wjgnet.com/2307-8960/full/v13/i16/102866.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i16.102866