Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

doi:10.12998/wjcc.v13.i16.102866

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Jun 6, 2025 (publication date) through Feb 13, 2025

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2025; 13(16): 102866
Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.102866

Table 5 Multivariate logistic analyses between pharmacokinetics and efficacy

Variables	OR	95%CI	Wald χ²	P value
Intercept	0.3617	0.011-8.888	0.6165	0.5375
Sex	0.5565	0.079-3.229	0.6345	0.5257
Age	0.3449	0.030-2.656	0.9746	0.3298
Weight	0.5051	0.089-2.624	0.8085	0.4188
Main etiologies of ICU cases	0.5206	0.076-3.206	0.7011	0.4833
Comorbidities	0.1924	0.016-1.535	1.4520	0.1464
Infectious site	0.9723	0.405-2.311	0.0651	0.9481
Daily dose	11.0400	1.752-109.200	2.3700	0.0178
C_min	75.0000	9.551-1201.000	3.6430	0.0003
AUC_0-24	28.7700	1.710-2026.000	1.9320	0.0353
AUC_0-24/MIC	0.1049	0.002-1.789	1.3610	0.1736
APACHE II score	0.5606	0.100-2.929	0.6910	0.4895
Mechanical ventilation	2.5520	0.363-22.680	0.9161	0.3596

APACHE: Acute physiological chronic health evaluation; AUC: Area under the curve; CI: Confidence interval; C_min: Trough concentration; ICU: Intensive care unit; MIC: Minimum inhibitory concentration; OR: Odds ratio.

Citation: Guo T, Du LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. World J Clin Cases 2025; 13(16): 102866
URL: https://www.wjgnet.com/2307-8960/full/v13/i16/102866.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i16.102866