Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

Table 3 Univariate logistic analyses between pharmacokinetics and clinical characteristics and efficacy, n (%)

Variable	Ineffective (n = 26)	Effective (n = 77)	OR	95%CI	P value
Sex			0.9815	0.360-2.517	0.9696
Female	8 (30.8)	24 (31.2)	-	-	-
Male	18 (69.2)	53 (68.8)	-	-	-
Age (years)			0.8780	0.358-2.150	0.7745
≤ 65	13 (50.0)	41 (53.2)	-	-	-
> 65	13 (50.0)	36 (46.8)	-	-	-
Weight (kg)			0.6029	0.231-1.492	0.2830
≤ 60	9 (34.6)	36 (46.8)	-	-	-
> 60	17 (65.4)	41 (53.2)	-	-	-
Main etiologies of ICU cases			0.5000	0.183-1.421	0.1805
Postoperative infection	18 (69.2)	63 (81.8)	-	-	-
Other	8 (30.7)	14 (18.2)	-	-	-
Comorbidities			0.5583	0.082-2.315	0.4720
No	2 (7.7)	10 (13.0)	-	-	-
Yes	24 (92.3)	67 (87.0)	-	-	-
Infectious site			0.7960	0.504-1.257	0.3235
Abdominal cavity	5 (19.2)	17 (22.1)	-	-	-
Lung	9 (34.6)	26 (33.8)	-	-	-
Blood	7 (26.9)	29 (37.7)	-	-	-
Chest cavity	5 (19.2)	5 (6.5)	-	-	-
Daily dose (g)			2.7840	0.892-8.484	0.0709
≤ 1.125	7 (26.9)	9 (77.0)	-	-	-
> 1.125	19 (73.1)	68 (88.3)	-	-	-
APACHE II score			0.7143	0.289-1.743	0.4597
≤ 35	12 (46.2)	42 (54.5)	-	-	-
> 35	14 (53.8)	35 (45.5)	-	-	-
Mechanical ventilation			1.1850	0.431-3.076	0.7320
No	8 (30.8)	21 (27.3)	-	-	-
Yes	18 (69.2)	56 (72.7)	-	-	-
Cmin			33.0000	10.440-130.700	< 0.0001
≤ 9.4	22 (84.6)	11 (14.3)	-	-	-
> 9.4	4 (15.4)	66 (85.7)	-	-	-
AUC0-24			19.6400	6.321-71.150	< 0.0001
≤ 359.6	15 (57.7)	5 (6.5)	-	-	-
> 359.6	11 (42.3)	72 (93.5)	-	-	-
AUC0-24/MIC			7.3960	2.405-24.680	0.0006
≤ 359.6	10 (38.5)	6 (7.8)	-	-	-
> 359.6	16 (61.5)	71 (92.2)	-	-	-

APACHE: Acute physiological chronic health evaluation; AUC: Area under the curve; CI: Confidence interval; C_min: Trough concentration; ICU: Intensive care unit; MIC: Minimum inhibitory concentration; OR: Odds ratio.