Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

doi:10.12998/wjcc.v13.i16.102866

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Jun 6, 2025 (publication date) through Mar 16, 2025

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2025; 13(16): 102866
Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.102866

Table 2 Effect of pharmacokinetic indices on nephrotoxicity

Characteristics	Non-nephrotoxic (n = 76)	Nephrotoxic (n = 27)	P value
Mean daily dose (g)	1.7 ± 0.5	1.9 ± 0.4	0.1371
C_min (μg/mL)	12.4 ± 6.3	13.3 ± 6.9	0.5211
AUC_0-24	484.9 ± 154.4	528.1 ± 245.6	0.2931
AUC_0-24/MIC	640.6 ± 322.0	635.7 ± 332.5	0.9458

AUC: Area under the curve; C_min: Trough concentration; MIC: Minimum inhibitory concentration.

Citation: Guo T, Du LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. World J Clin Cases 2025; 13(16): 102866
URL: https://www.wjgnet.com/2307-8960/full/v13/i16/102866.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i16.102866