Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit

doi:10.12998/wjcc.v13.i16.102866

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Jun 6, 2025 (publication date) through Feb 13, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jun 6, 2025; 13(16): 102866
Published online Jun 6, 2025. doi: 10.12998/wjcc.v13.i16.102866

Table 1 Effect of pharmacokinetic indices on efficacy

Characteristics	Ineffective (n = 26)	Effective (n = 77)	P value
Mean daily dose (g)	1.7 ± 0.5	1.8± 0.5	0.4689
C_min (μg/mL)	6.9 ± 3.3	14.5 ± 6.2	< 0.0001
AUC_0-24	342.8 ± 119.1	546.8 ± 171.8	< 0.0001
AUC_0-24/MIC	467.0 ± 248.1	696.2 ± 327.1	0.0015

AUC: Area under the curve; C_min: Trough concentration; MIC: Minimum inhibitory concentration.

Citation: Guo T, Du LY, Liu MF, Zhou XJ, Chen XR. Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit. World J Clin Cases 2025; 13(16): 102866
URL: https://www.wjgnet.com/2307-8960/full/v13/i16/102866.htm
DOI: https://dx.doi.org/10.12998/wjcc.v13.i16.102866