Genetic insights in infectious diseases: Insights from a case report and implications for personalized medicine

Figure 2 Detailed role of vitamin D receptor in immune response and elaborated role of solute carrier family 11 member 1 in immune response. A: This flowchart illustrates the activation and immune modulation pathways of vitamin D receptor, from vitamin D receptor activation to its role in innate and adaptive immunity, secretion of antibacterial peptides, and implications for disease susceptibility and immune dysregulation; B: This flowchart highlights the role of solute carrier family 11 member 1 in macrophage-mediated iron regulation, pathogen suppression, and the downstream effects of genetic polymorphisms on resistance to infections and drug resistance. VDR: Vitamin D receptor; VDRE: Vitamin D response elements; SLC11A1: Solute carrier family 11 member 1.