Challenging anticoagulation therapy for multiple primary malignant tumors combined with thrombosis: A case report and review of literature

Table 2 Anticoagulation regimens in different situations

	Mode of administration	Initial therapeutic dose	Maintenance of therapeutic dose	Extended treatment dose
Unfractionated heparin	Intravenous	Maintain APTT 1.5 times the upper limit of normal	/	/
Low molecular heparin	Subcutaneous	200 IU/kg/d for 1 month	150 IU/kg	/
Rivaroxaban	Oral	15 mg each time, twice a day for 3 wk	20 mg each time, once a day	20 mg each time, once a day
Apixaban	Oral	10 mg each time, twice a day for 1 wk	5 mg each time, twice a day	2.5 mg each time Twice a day
Eldosaban	Oral	At least 5 d of heparin introduction is required, with dose reduction after LMWH introduction, i.e. 30 mg each time, once a day	60 mg each time, once a day	60 mg each time, once a day

LMWH: Low molecular weight heparin; APTT: Activated partial thromboplastin time.