Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

Figure 3 Histological and immunohistochemical large cell neuroendocrine carcinoma. A: Tumor cells are arranged in nests, with relatively abundant basophilic cytoplasm, large round-to-oval nuclei and frequent mitosis in case 10; B: Small cell carcinoma of the ovary: Tumor cells are arranged in an organoid pattern, and some of the cells are spindle-shaped. The nucleus is oat-like, with abundant mitotic and apoptotic activity in case 4; C-E: Neuroendocrine carcinoma positive for CD56 (C), chromogranin A (D) and synaptophysin (E); F: Positive for cytokeratin.