Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

Figure 4 Orthogonal partial least square discriminant analysis and pathway enrichment analysis between the Helicobacter pylori-positive and -negative samples. A, B: Orthogonal partial least square (OPLS) score plots; C, D: S-plots; A, C: Negative electronspray ionization (ESI) mode; B, D: Positive ESI mode. Model parameters of the negative ESI mode: R2X = 0.472, R2Y = 0.944, and Q2 = 0.119; model parameters of the positive ESI mode: R2X = 0.424, R2Y = 0.985, and Q2 = −0.109; E: Pathway enrichment analysis of differential metabolites between the Helicobacter pylori-negative and -positive samples. Differential metabolites were obtained from the OPLS–discriminant analysis and subjected to Kyoto encyclopedia of genes and genomes analysis using MetaboAnalyst. Helicobacter pylori-positive; HP(−): Helicobacter pylori-negative.