Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

Figure 3 Orthogonal partial least square discriminant analysis and pathway enrichment analysis of the health and Helicobacter pylori-positive samples. A, B: Orthogonal partial least square (OPLS) score plots; C, D: S-plots; A, C: Negative electronspray ionization (ESI) mode; B, D: Positive ESI mode. Model parameters of the negative ESI mode: R2X = 0.537, R2Y = 0.935, and Q2 = −0.33. Model parameters of the positive ESI mode: R2X = 0.467, R2Y = 0.955, and Q2 = −0.0553; E: Pathway enrichment analysis of differential metabolites between Helicobacter pylori-negative and health samples. Differential metabolites were obtained from OPLS–discriminant analysis and subjected to Kyoto encyclopedia of genes and genomes analysis using MetaboAnalyst software. Helicobacter pylori-positive; HP(−): Helicobacter pylori-negative.