Clinical and Translational Research
Copyright ©The Author(s) 2024.
World J Clin Cases. Feb 16, 2024; 12(5): 880-890
Published online Feb 16, 2024. doi: 10.12998/wjcc.v12.i5.880
Table 1 Mendelian randomization estimates from different methods of assessing the causal effect between gastroesophageal reflux disease/Barret's esophagus and essential hypertension
ExposureOutcomeStepNsnpIVW
WM
MR-Egger
OR or beta
95%CI
P value
OR or beta
95%CI
P value
OR or beta
95%CI
P value
Gastroesophageal reflux diseaseEssential hypertension3691.461.33, 1.592.14E-161.341.19, 1.506.80E-072.0731.23, 3.500.0082
Duplicate essential hypertension1771.0021.0008, 1.0034.98E-041.00130.9998, 1.00280.0841.00180.996, 1.00760.54
Diastolic blood pressure13580.090.08, 0.121.2E-170.0950.066, 0.127.8E-110.034-0.12, 0.190.66
Systolic blood pressure13610.780.11, 1.440.0210.59-0.36, 1.530.234.420.28, 8.550.04
Hypertensive heart disease1751.681.36, 2.081.60E-061.821.38, 2.422.90E-052.990.85, 10.480.09
Hypertensive heart and/or renal disease2731.611.33, 1.941.00E-061.721.31, 2.268.91772E-052.890.96, 8.750.064
Barret's esophagusEssential hypertension1161.000060.9993, 1.00080.881.0000330.999, 1.0010.951.0020.997, 1.00670.4
Duplicate essentialhypertension1161.051.0004, 1.110.0481.0781.001, 1.160.0461.10.75, 1.610.62