Identification and validation of a new prognostic signature based on cancer-associated fibroblast-driven genes in breast cancer

Figure 14  Correlation between CAFPS and signaling pathways. A: Spearman’s correlation analyses revealing that CAFPS is significantly correlated with most hallmark gene sets; B: The ssGSEA data revealing that the cancer associated fibroblast (CAF) risk score is directly associated with TGF-BETA signaling pathways enrichment scores using The Cancer Genome Atlas (TCGA) database; C: The ssGSEA data revealing that the CAF risk score is directly associated with IL-6-JAK-STAT3 signaling pathways enrichment scores using the TCGA database; D: The ssGSEA data revealing that the CAF risk score is directly associated with The TNFA-SIGNALING-VIA-NFKB signaling pathways enrichment scores using the TCGA database.