psk1 virulence gene-induced pulmonary and systemic tuberculosis in a young woman with normal immune function: A case report

Figure 2 Whole-genome evolutionary tree of Mycobacterium tuberculosis. Additional Mycobacterium tuberculosis genomes were selected from the Virulence Factor Database (VFDB) (http://www.mgc.ac.cn/cgi-bin/VFs/genus.cgi?Genus=Mycobacterium), developed by the bioinformatics research team of the Institute of Pathogenic Biology, Chinese Academy of Medical Science, and a phylogenetic tree was built using the PhyML (maximum likelihood) software. The whole genomes of several strains, including CCDC5079, CCDC5180, Beijing NTR203, CDC1551, and classic H37Rv and H37Ra, were analysed for subsequent genome comparison, as these strains have previously shown strong dissemination ability. The patient’s strain (BLM-A21) was closer to CCDC5079, CCDC5180, and Beijing NTR203 as shown on the evolutionary tree.