Acellular dermal matrices in reconstructive surgery; history, current implications and future perspectives for surgeons

Table 3 Clinical evidence examples of the utilization of acellular dermal matrix in various chronic wounds

Ref.	Year	Title	Note
Luthringer et al[56]	2020	Human-derived Acellular Dermal Matrix Grafts for Treatment of Diabetic Foot Ulcers: A Systematic Review and Meta-analysis	Authors conclude that Human-derived acellular dermal matrices (ADMs) are associated with a higher likelihood of complete healing and fewer days to complete healing within a 12-week and 16-week periods when compared with standard of care
Gormley et al[52]	2024	The use of fetal bovine acellular dermal matrix in severe diabetic foot ulceration and threatened limbs with tissue loss the use of FBADM as an adjunct for complex wounds	Authors conclude that ADM may be a useful adjunct in the acute setting of complex diabetic foot disease and critical limb-threating ischemia ulceration to assist with wound healing
Climov et al[53]	2016	The Role of Dermal Matrices in Treating Inflammatory and Diabetic Wounds	Authors review wide range of inflammatory wounds such as pyoderma gangrenosum, sickle cell ulcer, sarcoid ulcer as well as diabetic foot ulcer where ADMs may enhance the regenerative potential
Zelen et al[55]	2018	An aseptically processed, acellular, reticular, allogenic human dermis improves healing in diabetic foot ulcers: A prospective, randomised, controlled, multicentre follow-up trial	This randomized controlled trial demonstrates the effectiveness of the human derived ADM in facilitating the closure of nonhealing diabetic foot ulcers refractory to standard of care
Cazzell[58]	2019	A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers	According to this multicenter, randomized, controlled, open-label trial, authors conclude that successful increase in healing rates and rate of percent wound closure in ADM application as compared with conventional care options
Strauss and Brietstein[59]	2012	Fetal Bovine Dermal Repair Scaffold Used for the Treatment of Difficult-to- Heal Complex Wounds	Authors conclude that ADMs can be used as part of an effective treatment regimen to heal complex wounds with exposed tendon/bone caused by varying etiologies