Acellular dermal matrices in reconstructive surgery; history, current implications and future perspectives for surgeons

Table 2 Clinical evidence examples of the utilization of acellular dermal matrix in burn

Ref.	Year	Title	Note
Li et al[45]	2015	Human acellular dermal matrix allograft: A randomized, controlled human trial for the long-term evaluation of patients with extensive burns	This randomized controlled clinical trial of human acellular dermal matrix (ADM) showed that the composite graft of human ADM with thinner split-thickness skin graft could provide acceptable esthetic outcomes, good functional recovery, and less scar formation at the donor site
Heimbach et al[33]	2003	Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment	Integra® has been found useful in postburn reconstructive procedures both for pediatric and adult patients, affording improved cosmetic results. It clearly provides a valuable, effective and safe clinical treatment modality for dealing with the difficult clinical management challenge posed by the extensively burned patient
Nguyen et al[32]	2010	An objective long-term evaluation of Integra (a dermal skin substitute) and split thickness skin grafts, in acute burns and reconstructive surgery	Authors conclude that when objectively measured ADM treated sites correlate well with subject’s normal skin elasticity whilst no correlation was seen with the subject’s skin grafted sites
Guo et al[35]	2016	Use of porcine acellular dermal matrix following early dermabrasion reduces length of stay in extensive deep dermal burns	In this retrospective study authors conclude that early dermabrasion combined with porcine ADM coverage facilitates wound healing, decreases the length of hospital stay, and improves esthetic and functional results in extensive deep dermal burns of adult patients
Wang et al[51]	2020	Clinical Applications of Allograft Skin in Burn Care	This compact review summarizes the current use of ADMs and skin allografts in burns in the light of clear evidence
Chen et al[47]	2024	Multicenter effect analysis of one-step acellular dermis combined with autologous ultra-thin split thickness skin composite transplantation in treating burn and traumatic wounds	In this open, randomized, controlled, multicenter study, the authors suggest that ADMs can be successfully combined with partial-thickness skin grafts in many other acute traumatic and chronic non-burn wounds