Diagnostic and management challenges in primary cutaneous anaplastic large cell lymphoma with necrosis, inflammation, and surgical intervention: A case report

Figure 3 Morphologic and vascular features of tumor necrosis. A and B: Microscopically, in the background of multifocal geographic tumor necrosis, highly pleomorphic lymphoid cell infiltration is noted; C: Vascular invasion with surrounding necrosis is identified and marked with white arrow; D: In situ hybridization for Epstein–Barr virus-encoded RNA (EBER) showing reactivity (A: H&E, × 5; B: H&E, × 20; C: H&E, × 10; D: EBER in situ hybridization, × 20).