Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes

Figure 2 Identification of primary biliary cholangitis-associated gene modules in the Gene Expression Omnibus dataset using weighted gene co-expression network analysis. A: A dendrogram was generated by clustering genes in the GSE79850 dataset using a topological overlap matrix (1-TOM). Each branch represents a gene, with co-expression modules visualized in different colors; B: A module-trait heatmap displayed the correlation between gene modules and primary biliary cholangitis (PBC) in the GSE79850 dataset. Each module is associated with a correlation coefficient and p-value, indicating the strength and significance of the correlation; C: A scatter plot illustrated the correlation between the turquoise module and PBC in the GSE79850 dataset. The turquoise module exhibits the strongest positive correlation with PBC.