Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

Figure 3 MiRNA regulation in the advanced glycation end product/receptor of advanced glycation end products activated nuclear factor pathway. Advanced glycation end product - receptor of advanced glycation end product interaction activates the nuclear factor pathway, which is inhibited by miR-200b, miR-200c, and miR-471-3p and upregulated by miR-124 and miR-146a. AGE: Advanced glycation end product; RAGE: Receptor of advanced glycation end product; MAPK: Mitogen-activated protein kinases; NF-κB: Nuclear factor kappa beta; TNF-α: Tumor necrosis factor.