Impact of body mass index on adverse kidney events in diabetes mellitus patients: A systematic-review and meta-analysis

Table 2 Subgroup analyses of serum creatinine and estimated glomerular filtration rate due to body mass index

Serum creatinine								eGFR
Subgrouped	By No. of trials	SMD	95%CI		P value	I2 (%)	P for heterogeneity	By No. of trials	SMD	95%CI		P value	I2 (%)	P for heterogeneity
Country
Asian	4	-0.08	-0.41	0.26	0.66	84.60	< 0.001	6	-0.01	-0.24	0.23	0.96	90	< 0.00001
European	3	0.15	0.06	0.25	< 0.001	0.00	0.71	1	-0.11	-0.28	0.06	0.12	-	-
Age
≤ 60	3	-0.18	-0.59	0.24	0.41	83.40	< 0.001	3	-0.32	-0.86	0.21	0.23	90.50	< 0.001
> 60	4	0.17	0.11	0.23	< 0.001	0.00	0.86	4	0.27	0.19	0.35	< 0.001	22.00	0.28
Subject type
Retrospective	5	0.02	-0.16	0.20	0.81	0.80	< 0.001	5	-0.01	-0.29	0.27	0.92	0.92	< 0.001
Prospective	2	0.16	-0.01	0.33	0.06	0.00	0.93	2	0.10	-0.06	0.26	0.20	0.00	0.80
Sample size
≤ 500	3	-0.20	-0.57	0.18	0.31	0.65	0.06	4	-0.22	-0.63	0.18	0.28	86.20	< 0.001
> 500	4	0.17	0.11	0.22	< 0.001	0.00	0.86	3	0.28	0.21	0.36	< 0.001	21.70	0.28

eGFR: Estimated glomerular filtration rate; BMI: Body mass index; SMD: Standard mean deviation; CI: Confidence interval.