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©The Author(s) 2024.
World J Clin Cases. Jan 26, 2024; 12(3): 525-537
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.525
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.525
Table 2 Role of miRNA in various metabolic pathways
No. | miRNA | Target pathway | Model | Disease | Effect | Ref. |
1 | miR-21 | NF-κβ | db/db mice | Metabolic syndrome and obesity | Up-regulated | [48] |
2 | miR-124 | NF-κβ | Primary rat retinal microglial cells | Down-regulated | [49] | |
3 | miR-471-3p | NF-κβ | Raw264.7 cells and db/db mice | Diabetic cardiomyopathy | Up-regulated | [50] |
4 | miR-46a | NF-κβ | Human blood | Hyperlipidemia | Up-regulated | [51] |
5 | miR-200b | NF-κβ | Huvec line | Down-regulated | [52] | |
6 | miR-200c | NF-κβ | Huvec line | Down-regulated | [52] | |
7 | miR-210 | PKC | Down-regulated | [54] | ||
8 | miR-25 | PKC | Adult male balb/c mice and diabetic db/db mice | Diabetic peripheral neuropathy | Down-regulated | [55] |
9 | miR-21-3p | PKC | Human aortic vsmcs (C-12511, promocell, and human vets | Diabetic atherosclerosis | Down-regulated | [56] |
10 | miR-92a | PKC | db/db mice | Diabetes mellitus | Up-regulated | [57] |
11 | miR-185 | NO | Three-month-old male sprague–dawley rats | Diabetes mellitus | Down-regulated | [59] |
12 | miR-195 | NO | Mvec cell lines | Deep vein thrombosis | Down-regulated | [60] |
13 | miR-582 | NO | Mvec cell lines | Deep vein thrombosis | Down-regulated | [60] |
14 | miR-191 | PI3K/AKT | Male C57bl/6j mice | Up-regulated | [62] | |
15 | miR-29b-3p | PI3K/AKT | Human serum and Hek-293t cells | Diabetic retinopathy | Up-regulated | [62] |
16 | miR-29c-3p | PI3K/AKT | Rat | Diabetes mellitus | Up-regulated | [62] |
17 | miR-199a-5p | PI3K/AKT | Rat | Diabetes mellitus | Down-regulated | [62] |
18 | miR-532-3p | PI3K/AKT | Rat | Diabetes mellitus | Down-regulated | [62] |
19 | miR-93-5p | PI3K/AKT | Rat | Diabetes mellitus | Down-regulated | [62] |
20 | miR-150-5p | PI3K/AKT | Rat | Diabetes mellitus | Down-regulated | [63] |
21 | miR-345-3p | PI3K/AKT | Rat | Diabetes mellitus | Down-regulated | [64] |
22 | miR-25-3p | PI3K/AKT | Human blood | Diabetic retinopathy | Down-regulated | [65] |
23 | miR-214 | PI3K/AKT | Male sprague dawley rats | Diabetic nephropathys | Down-regulated | [66] |
24 | miR-203 | PI3K/AKT | Rat | Diabetic foot ulcer | Up-regulated | [67] |
25 | miR-129-5p | PI3K/AKT | Sprague dawley rats | Intracerebral Haemorrhage | Down-regulated | [68] |
26 | miR-146b-3p | PI3K/AKT | Human blood | Down-regulated | [69] |
- Citation: Shrivastav D, Singh DD. Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus. World J Clin Cases 2024; 12(3): 525-537
- URL: https://www.wjgnet.com/2307-8960/full/v12/i3/525.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v12.i3.525