Omadacycline in the treatment of scrub typhus: Three case reports

Table 1 Laboratory findings for cases

Item	Case 1	Case 2	Case 3	Reference range
Routine blood work
WBC (× 109/L)	7	3.4	6.7	3.5-9.5
RBC (× 1012/L)	3.73	2.89	4.24	3.8-5.1
Hb (g/L)	100	87	131	115-150
PLT (× 109/L)	155	119	242	125-350
Neutrophil count (× 109/L)	2.68	1.91	3.4	1.8-6.3
Neutrophil percentage (%)	38.3	56.2	50.7	40-75
Lymphocyte count (× 109/L)	3.99	1.33	3.01	1.1-3.2
Eosinophil count (× 109/L)	0	0.01	0	0.02-0.52
Indices of inflammation
CRP (mg/L)	28.04	52.01	87.41	0-10
IL-6 (pg/mL)	4	0.03	-	0-7
PCT (ng/mL)	0.11	0.05	0.25	0-0.5
Biochemical indexes
TBIL (umol/L)	4.9	8.9	9.6	0-21
DBI (umol/L)	2	4.6	0	0-8
IBIL (umol/L)	2.9	4.3	9.6	0-16
ALB (g/L)	38.4	28.9	-	40-55
ALT (U/L)	35.1	84.9	144	7-40
AST (U/L)	39.5	74.5	83	13-35
LDH (U/L)	433	611	387	135-214
ADH (U/L)	55.7	51	-	0-20
BUN (mmol/L)	3.97	4.2	3.18	2.6-7.5
Scr (umol/L)	54.5	49.8	67.7	41-73
Coagulation function
PT (seconds)	13.2	13.5	13.7	12-14
APTT (seconds)	42.4	48.1	40.5	28-40
FIB (g/L)	3.57	2.47	5.23	2-4
D-dimer (ug/mL)	1.14	10.8	1.46	0-0.5
Electrolyte concentrations
Na + (mmol/L)	137.9	131.3	134.6	137-147
K + (mmol/L)	3.3	3.53	3.91	3.5-5.3
Cl- (mmol/L)	105.7	98	101.2	99-110
Ca2 + (mmol/L)	2.15	1.96	2.13	2.11-2.52
Infectious disease
HBV	Positive	Negative	Negative
HCV	Negative	Negative	Negative
HIV	Negative	Negative	Negative
Syphilis	Negative	Negative	Negative
Respiratory pathogen spectrum	Negative	Negative	Negative
Antinuclear antibody profile	Negative	Negative	Negative
EBV quantification	Normal	Normal	Normal
T-SPOT	-	-	Negative

WBC: White blood cell; RBC: Red blood cell; Hb: Hemoglobin concentration; PLT: Platelet; CRP: C-reactive protein; IL-6: Interleukin-6; PCT: Procalcitonin; TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LDH: Lactic dehydrogenase; ADH: Adenosine dehydrogenase; BUN: Blood urea nitrogen; Scr: Serum creatinine; PT: Prothrombin time; APTT: Activated partial thromboplastin time; FIB: Fibrinogen; HBV: Hepatitis B; HCV: Hepatitis C; HIV: Human immunodeficiency virus; EBV: Epstein-Barr virus; T-SPOT: Tuberculosis infection T cell spot test.