Correlation between TEX14 and ADAM17 expressions in colorectal cancer tissues of elderly patients and neoplasm staging, invasion, and metastasis

Table 5 Correlation between ADAM17 protein expression and clinical pathology

Pathological characteristic		n	ADAM17		χ2 value	P value
			Positive, n = 67	Negative, n = 19
Age	≥ 65 years	54	44 (81.48)	10 (18.52)	1.077	0.299
	< 65 years	32	23 (71.88)	9 (28.13)
Sex	Male	47	39 (82.98)	8 (17.02)	1.549	0.213
	Female	39	28 (71.79)	11 (28.21)
Pathological type	Tubular adenocarcinoma	33	27 (81.82)	6 (18.18)	1.308	0.520
	Villous adenocarcinoma	27	19 (70.37)	8 (29.63)
	Papillary carcinoma	26	21 (80.77)	5 (19.23)
Tumor diameter	≥ 3 cm	46	38 (82.61)	8 (17.39)	1.270	0.260
	< 3 cm	40	29 (72.50)	11 (27.50)
Differentiation degree	Low differentiation	27	20 (74.07)	7 (25.93)	10.079	0.006
	Moderate differentiation	25	15 (60.00)	10 (40.00)
	High differentiation	34	32 (94.12)	2 (5.88)
TNM staging	Stages I-II	37	24 (64.86)	13 (35.14)	6.418	0.011
	Stages III-IV	49	43 (87.76)	6 (12.24)
Lymph node metastasis	Presence	53	46 (86.79)	7 (13.21)	6.336	0.012
	Absence	33	21 (63.64)	12 (36.36)
Infiltration degree	T1 + T2	37	24 (64.86)	13 (35.14)	7.250	0.027
	T3	41	35 (85.37)	6 (14.63)
	T4	8	8 (100.00)	0 (0)
Distant metastasis	Presence	46	40 (86.96)	6 (13.04)	4.706	0.030
	Absence	40	27 (67.50)	13 (32.50)

Data are n (%). ADAM17: A disintegrin and metalloprotease 17.