Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study

Table 4 MVMR estimating causal associations between each mediator and cholelithiasis with adjustment for education, cognition, or intelligence

Exposure	Mediator	β (95%CI)	OR (95%CI)	P value
Education	BMI	0.469 (0.369-0.569)	1.60 (1.45-1.77)	4.97E-20
	BF%	0.665 (0.525-0.805)	1.94 (1.69-2.24)	1.45E-20
	Waist circumference	0.447 (0.282-0.612)	1.56 (1.33-1.84)	1.13E-07
	WHR	0.361 (0.130-0.592)	1.43 (1.14-1.81)	2.19E-03
	Time spent watching TV	0.372 (0.173-0.571)	1.45 (1.06-1.75)	4.29E-02
Cognition	Time spent watching TV	0.357 (0.071-0.643)	1.42 (1.07-1.90)	1.44E-02
Intelligence	Time spent watching TV	0.382 (0.056-0.708)	1.46 (1.05-2.03)	2.17E-02

BMI: Body mass index; TV: Television; WHR: Waist-to-hip ratio.