Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study

Table 2 MVMR estimating causal associations between education, cognition, or intelligence and cholecystitis with adjustment for cholelithiasis

Exposure	Method	β (95%CI)	OR (95%CI)	P value
Education	MR MV_IVW	-0.534 (-0.767 to -0.300)	0.292 (0.171-0.501)	1.73E-43
	MR MV_Egger	-0.614 (-0.853 to -0.376)	0.243 (0.140-0.421)	< 0.001
	MR MV_Median	-0.608 (-0.942 to -0.275)	0.247 (0.114-0.531)	< 0.001
	MR MV_Lasso	-0.513 (-0.738 to -0.288)	0.307 (0.183-0.515)	< 0.001
Cognition	MR MV_IVW	-0.026 (-0.222 to 0.222)	0.942 (0.600-1.667)	0.839
	MR MV_Egger	-0.894 (-1.590 to -0.197)	0.128 (0.026-1.574)	0.012
	MR MV_Median	0.094 (-0.234 to 0.421)	1.242 (0.583-2.636)	0.576
	MR MV_Lasso	-0.025 (-0.247 to 0.196)	0.944 (0.566-1.570)	0.822
Intelligence	MR MV_IVW	-0.079 (-0.296 to 0.138)	0.834 (0.506-1.374)	0.475
	MR MV_Egger	-0.454 (-1.171 to 0.264)	0.352 (0.067-1.837)	0.215
	MR MV_Median	-0.105 (-0.414 to 0.203)	0.785 (0.385-1.596)	0.504
	MR MV_Lasso	-0.122 (-0.328 to 0.084)	0.755 (0.470-1.213)	0.246

MR: Mendelian randomization.