Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study

doi:10.12998/wjcc.v12.i20.4272

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 20

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (1866)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-3) series, Tables (1-4) series.

Item

Count

PDF

HTML

916

Figures (1-3)

153

Tables (1-4)

129

Sum=1254

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

116

Download

246

Sum=362

Publishing Process of This Article

Item

Count

Browse

Download

144

Sum=185

Jul 16, 2024 (publication date) through Feb 11, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. Jul 16, 2024; 12(20): 4272-4288
Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4272

Table 1 Summary of GWAS data in Mendelian randomization analyses

Phenotype	Unit	No. of participants	Ancestry	Consortium/cohort	Ref.	GWAS resources
Education	SD (4.2 years)	1131881	European	SSGAC	Lee et al[32], 2018
Cognition	SD (0.99 point)	257841	European	COGENT	Lee et al[32], 2018
Intelligence	SD	269867	European	Meta	Savage et al[25], 2018
Cholelithiasis	Event	330903	European	FinnGen	Not available	https://r9.finngen.fi/
Cholecystitis	Event	330903	European	FinnGen	Not available	https://r9.finngen.fi/

BMI	SD (4.7 kg/m²)	681275	European	GIANT	Yengo et al[34], 2018
BF%	SD (6.6%)	65831	European	Meta	Lu et al[35], 2016
WHR	SD (0.09)	212244	European	GIANT	Shungin et al[36], 2015
Waist circumference	SD (12.5 cm)	231353	European	GIANT	Shungin et al[36], 2015
Watching TV	SD (1.5 h)	408815	European	United Kingdom Biobank	Van de Vegte et al[44], 2020
Childhood obesity	Event	13848	European	EGG	Bradfield et al[37], 2012
Type 2 diabetes	Event	70127	European	Meta	Sílvia Bonàs-Guarch et al[38], 2018
Fasting insulin	SD (0.79 pmol/L)	108557	European	MAGIC	Scott et al[39], 2012
Fasting glucose	SD (0.73 mmol/L)	133010	European	MAGIC	Scott et al[39], 2012
LDL-C	SD (38.7 mg/dL)	173082	Mixed¹	GLGC	Willer et al[40], 2013
HDL-C	SD (15.5 mg/dL)	187167	Mixed¹	GLGC	Willer et al[40], 2013
Triglycerides	SD (90.7 mg/dL)	177861	Mixed¹	GLGC	Willer et al[40], 2013
Total cholesterol	SD (41.8 mg/dL)	187365	Mixed¹	GLGC	Willer et al[40], 2013
Smoking initiation	Event	607291	European	GSCAN	Liu et al[41], 2019
Smoking heaviness	SD (8 cigarettes)	337334	European	GSCAN	Liu et al[41], 2019
Alcohol drinking	SD (9 drinks/wk)	335394	European	GSCAN	Liu et al[41], 2019
Coffee intake	SD (1% change)	375833	European	United Kingdom Biobank	Zhong et al[42], 2019
Tea intake	SD (2.85 cups/d)	447485	European	United Kingdom Biobank	Zhong et al[42], 2019	UKB-b-6066
MVPA	SD (2084 MET-min/wk)	377234	European	United Kingdom Biobank	Klimentidis et al[43], 2018
Computer using	SD (1.2 h)	408815	European	United Kingdom Biobank	Van de Vegte et al[44], 2020
Total house income	SD	397751	European	United Kingdom Biobank	Hemani et al[45], 2018

¹Thirty-seven of forty-five studies for summary statistics consisted preliminarily of participants of European ancestry.

BF%: Body fat percentage; BMI: Body mass index; COGENT: Cognitive Genomics Consortium; EGG: Early Growth Genetics Consortium; GIANT: Genetic Investigation of Anthropometric Traits; GLGC: Global Lipids Genetics Consortium; GSCAN: GWAS & Sequencing Consortium of Alcohol and Nicotine use; GWAS: Genome-wide association study; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; MR: Mendelian randomization; MVMR: Multivariable Mendelian randomization; MVPA: Moderate to vigorous physical activity; PGC: Psychiatric Genomic Consortium; SSGAC: Social Science Genetic Association Consortium; TV: Television; WHR: Waist-to-hip ratio.

Citation: Li CL, Liu YK, Lan YY, Wang ZS. Association of education with cholelithiasis and mediating effects of cardiometabolic factors: A Mendelian randomization study. World J Clin Cases 2024; 12(20): 4272-4288
URL: https://www.wjgnet.com/2307-8960/full/v12/i20/4272.htm
DOI: https://dx.doi.org/10.12998/wjcc.v12.i20.4272