Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients

Table 3 Comparison of the serological and biochemistry data and indexes of cardiac function between type 2 diabetes mellitus patients with and without colorectal polyps

Parameter	Polyp group	Non-polyp group	t/chi-square/Z-value	P value
ALT in U/L	17.00 (12.25, 24.00)	18.00 (13.00, 26.00)	−0.558	0.577
AST in U/L	18.00 (15.00, 22.00)	18.00 (15.00, 22.00)	−0.009	0.993
TP in g/L	66.60 (61.75, 70.65)	66.20 (63.40, 71.10)	−0.715	0.475
Alb in g/L	40.47 ± 4.75	41.15 ± 3.52	1.181	0.239
UA in µmol/L	359.88 ± 100.63	348.97 ± 90.37	0.843	0.400
Cr in µmol/L	71.50 (59.00, 82.75)	65.00 (57.00, 76.00)	−2.132	0.033a
TC in mmol/L	4.16 (3.51, 4.84)	4.23 (3.54, 4.70)	−0.451	0.652
TG in mmol/L	1.56 (1.14, 2.09)	1.52 (1.01, 2.22)	−0.004	0.997
HDL-C in mmol/L	1.09 ± 0.29	1.16 ± 0.25	1.869	0.063
LDL-C in mmol/L	2.63 ± 0.81	2.45 ± 0.76	1.682	0.094
eGFR in mL/min × 1.73 m2	88.23 (75.79, 97.76)	95.42 (81.07, 101.79)	−3.171	0.002a
Urinary ACR in mg/g	7.48 (3.11, 21.47)	5.52 (3.34, 11.79)	−2.410	0.016a
Ejection fraction in %	68.40 (64.45, 72.50)	68.30 (64.70, 73.45)	−0.102	0.919
E/A ratio	0.76 (0.64, 0.94)	0.79 (0.65, 0.93)	−0.504	0.614
CRP in mg/L	0.80 (0.50, 1.87)	0.70 (0.50, 1.90)	−0.394	0.693
HbA1C in %	6.80 (6.10, 7.50)	6.80 (6.48, 7.40)	−0.978	0.328
HOMA-IR score	2.64 (1.53, 4.08)	2.69 (1.70, 4.12)	−0.196	0.845

^aP < 0.05.

Data are presented as medians (P25, P75) or mean ± standard deviation.

Alb: Serum albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; Cr: Serum creatinine; CRP: C-reactive protein; E/A ratio: Ratio of the maximum flow velocity of mitral valve in the early diastole of the left ventricle to that of the systolic mitral valve in the left atrium; eGFR: estimated Glomerular filtration rate; HbA1c: Glycosylated hemoglobin; HDL-C: High-density lipoprotein cholesterol; HOMA-IR: Homeostatic model assessment for insulin resistance; LDL-C: Low-density lipoprotein cholesterol; TC: Total cholesterol; TG: Triglyceride; TP: Serum total protein; UA: Serum uric acid; urinary ACR: Urinary microalbumin/creatinine ratio.