Association between gut microbiota and hepatocellular carcinoma and biliary tract cancer: A mendelian randomization study

Table 1 Causal associations between genetically predicted 13 microbial taxa and hepatocellular carcinoma and biliary tract cancer

Outcome	Exposure	Method	nSNP	β	SE	OR (95%CI)	P value
Biliary tract cancer
	Genus Eubacterium hallii group	IVW	11	0.838	0.351	2.31 (1.16-4.61)	0.017
	Genus Candidatus Soleaferrea	IVW	9	0.802	0.377	2.23 (1.06-4.67)	0.034
	Genus Dorea	IVW	7	-1.232	0.603	0.29 (0.09-0.95)	0.041
	Genus Flavonifractor	IVW	5	1.619	0.702	5.05 (1.27-19.9)	0.021
	Genus Lachnospiraceae FCS020 group	IVW	11	0.710	0.335	2.03 (1.06-3.92)	0.034
	Genus Lachnospiraceae ND3007 group	IVW	3	-2.430	1.214	0.09 (0.01-0.95)	0.045
	Order Victivallales	IVW	6	0.791	0.334	2.21 (1.15-4.25)	0.018
	Class Lentisphaeria	IVW	6	0.791	0.334	2.21 (1.15-4.25)	0.018
Hepatocellular carcinoma
	Genus Desulfovibrio	IVW	9	0.324	0.159	1.38 (1.01-1.89)	0.042
	Genus Oscillibacter	IVW	9	0.345	0.151	1.41 (1.05-1.90)	0.023
	Family Coriobacteriaceae	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048
	Order Coriobacteriales	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048
	Class Coriobacteriia	IVW	15	0.377	0.190	1.46 (1.00-2.12)	0.048

IVW: Inverse-variance weighted; OR: Odds ratio; Nsnp: Number of Single nucleotide polymorphism; SE: Standard error.