Serum cystatin C, monocyte/high-density lipoprotein-C ratio, and uric acid for the diagnosis of coronary heart disease and heart failure

Table 3 Diagnostic value of serum cystatin C, monocyte/high-density lipoprotein cholesterol ratio, and uric acid for coronary heart disease and heart failure

Biomarkers	Cut-off value	Sensitivity	Specificity	PPV	NPV	Accuracy	AUC (95%CI)
Cys-C for CHD	1.2 mg/L	80	85	80	85	82.5	0.86 (0.77–0.95)
MHR for CHD	0.9 × 109	85	80	77	87	82.5	0.87 (0.78–0.96)
UA for CHD	389 μmol/L	75	90	86	81	82.5	0.86 (0.77–0.95)
Cys-C for HF	1.4 mg/L	85	80	77	87	82.5	0.88 (0.79–0.97)
MHR for HF	1.0 × 109	80	85	80	85	82.5	0.87 (0.78–0.96)
UA for HF	449 μmol/L	80	85	80	85	82.5	0.88 (0.79–0.97)
Cys-C for CHD + HF	1.6 mg/L	90	85	82	92	87.5	0.93 (0.86–1.00)
MHR for CHD + HF	1.1 × 109	85	90	85	90	87.5	0.91 (0.83–0.99)
UA for CHD + HF	508 μmol/L	85	90	85	90	87.5	0.92 (0.84–1.00)

CysC: Cystatin C; MHR: Monocyte/high-density lipoprotein cholesterol ratio; UA: Uric acid; CHD: Coronary heart disease; HF: Heart failure; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the curve.