Development and validation of a circulating tumor DNA-based optimization-prediction model for short-term postoperative recurrence of endometrial cancer

Table 2 Results of the univariate Cox regression analysis of related factors in patients with endometrial cancer (N = 437)

Variables	HR	95%CI	P value
Age	0.803	0.457-1.413	0.447
Histological type	3.508	2.018-6.099	0.001
Smoking	3.409	1.593-7.298	0.002
Hypertension	1.227	0.597-2.524	0.578
ctDNA	13.009	6.655-25.431	0.001
Diabetes	0.524	0.163-1.684	0.278
Myometrial invasion	3.762	1.879-7.533	0.001
Grade	5.652	3.465-9.218	0.001
FIGO	2.015	1.507-2.694	0.001
Postoperative adjuvant therapy	0.487	0.280-0.848	0.011
Lymph node metastasis	5.612	2.874-10.959	0.001
Postoperative CA125	8.024	3.896-16.529	0.001

ctDNA: Circulating tumor DNA; CA125: Carcinoembryonic antigen 125; HR: Hazard ratio; FIGO: International Federation of Gynecology and Obstetrics.