Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis

Table 2 Comparison of biochemical parameters at presentation (mean ± SD)

	Non-diabetes (n = 30)	Prediabetes (n = 19)	T2DM (n = 29)	P value
Serum potassium (mEq/L)	3.1 ± 0.6	3.0 ± 0.7	3.1 ± 0.5	NS
Serum Sodium (mEq/L)	139.1 ± 2.6	139.1 ± 2.1	139.9 ± 2.2	NS
PAC (ng/dL)	28.2 ± 21.1	31.95 ± 26.2	39.8 ± 55.8	NS
PRA (ng/ml/h)	0.4 ± 0.2	0.32 ± 0.2	0.3 ± 0.2	NS
ARR (ng/dL per ng/mL/h)	148.1 ± 253	270.7 ± 393.9	266.2 ± 506.8	NS
Aldo:K	10.7 ± 12.2	12.5 ± 12.9	15.3 ± 29.7	NS
PAC post SST (ng/dL)	15.6 ± 11.8	16.5 ± 13.6	15.8 ± 12.1	NS
Venous Bicarbonate (mEq/L)	24.3 ± 7.1	26 ± 5.0	23.6 ± 4.5	NS
Creatinine (mg/dL)	1.2 ± 0.5	1.1 ± 0.2	1.2 ± 0.2	NS
eGFR (mL/min/1.73 m2)	70.6 ± 24.2	76.7 ± 19.8	71.2± 16.2	NS

NS: Non-significant, P ≥ 0.05; P < 0.05: Statistically significant; T2DM: Type 2 diabetes mellitus; PAC: Plasma aldosterone concentration; PRA: Plasma renin activity; ARR: Aldosterone to renin ratio, Aldo:K: Aldosterone to potassium ratio; PAC post SST: Plasma aldosterone concentration post saline suppression test; eGFR: Estimated glomerular filtration rate.