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World J Clin Cases. Jun 16, 2024; 12(17): 2951-2965
Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.2951
Table 1 Anatomical changes in the periocular region can lead to a “sunken eyeball” appearance
Periocular region
Anatomical changes
SkinThinning of eyelids, reduction of collagen deposition, distortion of elastin fibers, increased laxity
Subcutaneous tissueDescent of facial fat pads, atrophy of subcutaneous tissue, and subsequent volume loss
MuscleHypertrophy of orbicularis oculi muscle (can accentuate wrinkles) and hyperlaxity of orbito-malar ligament
BoneReceding of superior and inferior orbital rims