Establishment and evaluation of a prognostic model for patients with unresectable gastric cancer liver metastases

Table 2 Cox regression analysis of factors for outcome in the derivation cohort

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	0.96 (0.75-1.23)	0.108	0.84 (0.69-1.02)	0.074
Sex, n (%)			0.96 (0.82-1.11)	0.557
Men	Reference
Women	0.89 (0.76-1.05)	0.286
BMI, kg/m2	0.97 (0.96-0.99)	0.045	1.19 (0.87,1.64)	0.158
Albumin, g/L	0.64 (0.44-0.95)	0.016	0.95 (0.91, 0.99)	0.016
Hemoglobin, g/L	1.02 (0.98-1.06)	0.361
CEA, ng/ml	0.98 (0.92-1.04)	0.170
AFP, μg/L	0.46 (0.10-2.05)	0.251
ALT, U/L	0.91 (0.83-1.01)	0.224
AST, U/L	1.01 (0.43-2.33)	0.668
GGT, U/L	0.99 (0.94-1.06)	0.145
TG, mmol/L	0.76 (0.47-1.25)	0.130
TC, mmol/L	0.88 (0.41-1.88)	0.254
Drinking habit
Yes	Reference
No	1.19 (0.49-2.88)	0.638
Primary tumor size, cm	1.49 (1.03-2.16)	0.009	1.12 (1.05-1.25)	0.031
Surgery
Yes	0.49 (0.33-0.73)	0.001	0.38 (0.19-0.70)	0.005
No	Reference		Reference
Extrahepatic metastases
Yes	2.12 (1.35-3.34)	0.001	2.20 (1.30-3.64)	0.004
No	Reference		Reference
Chemotherapy
Yes	0.66 (0.48-0.90)	0.006	0.45 (0.24-0.85)	0.010
No	Reference		Reference
Primary site
Proximal	Reference
Gastric body	1.48 (0.51-3.25)	0.213
Distal	1.07 (0.89-1.30)	0.320
Multiple or whole stomach/anastomosis	1.00 (0.57-1.74)	0.971
Metastases size(max)	0.93 (0.48-1.84)	0.119
Metastases site
Left liver	Reference
Right liver	1.31 (0.72-2.38)	0.192
Whole liver	0.65 (0.30-1.38)	0.183
Hilar	0.55 (0.18-1.65)	0.610
Other	1.56 (0.67-3.62)	0.214

BMI: Body mass index; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; TC: Total cholesterol; TG: Triglyceride; AST: Aspartate transferase; GGT: Gamma-glutamyl transferase; ALT: Alanine aminotransferase; HR: Hazard ratio.