Systematic review and network meta-analysis of different non-steroidal anti-inflammatory drugs for juvenile idiopathic arthritis

Table 1 General characteristic of the included studies

Ref.	Sample size			Mean age			Subtype	t1	t2	t3	DMARDs (%)	Biologic agents (%)	CS (%)	Treatment duration (wk)
	t1	t2	t3	t1	t2	t3
Ruperto et al[17], 2005	73	74	78	8.9	9.0	7.5	pJIA, oJIA	Meloxicam (0.125 qd)	Meloxicam (0.250 qd)	Naproxen (5.000 mg/kg)	24.7/28.4/37.2	NS	19.3/22.0/14.9	12
Foeldvari et al[18], 2009	77	82	83	10.4	10.2	10.4	pJIA, oJIA	Celecoxib (3.0 mg/kg bid)	Celecoxib (6.0 mg/kg bid)	Naproxen (7.5 mg/kg)	50.6/47.6/51.8	0/3.7/3.6	NS	12
García-Morteo et al[19], 1987	12	14		8.5	8.5		pJIA, oJIA	Piroxicam	Naproxen (12.5 mg/kg/d)		NS	NS	11.5	12
Giannini et al[20], 1990	45	47		7.7	7.7		pJIA, oJIA, sJIA	Inuprofen (30-40 mg/kg/d)	Aspirin (60-80 mg/kg/d)		0	0	NS	12
Haapasaari et al[21], 1983	15	15	15	NS	NS	NS	pJIA, oJIA, sJIA	Diclofenac (2-3 mg/kg/d)	Aspirin (50-100 mg/kg/d)	Placebo	NS	NS	NS	2
Kvien et al[22], 1984	40	40		11.4	9.0		pJIA, oJIA	Naproxen (10 mg/kg/d)	Aspirin (75 mg/kg/d)		0	0	0	24
Levinson et al[23], 1977	53	54		9.4	9.0		pJIA, oJIA, sJIA	Tolmetin (15 mg/kg/d)	Aspirin (55 mg/kg/d)		NS	0	0	12
Reiff et al[24], 2006	109	100	101	9.7	9.4	10.7	pJIA, oJIA	Rofecoxib (0.3 mg/kg qd)	Rofecoxib (0.6 mg/kg)	Naproxen (7.5 mg/kg/d)	53.2/51.0/45.5	NS	19.3/22.0/14.9	12

CS: Corticosteroid; pJIA: Polyarticular juvenile idiopathic arthritis; oJIA: Oligoarticular juvenile idiopathic arthritis; sJIA: Systemic juvenile idiopathic arthritis; DMARDs: Disease-modifying anti-rheumatic drugs; NS: Not significant.