COVID-19 related liver injuries in pregnancy

Table 1 Coronavirus disease 2019-related liver injuries in pregnant women

Ref.	Number of patients	Type of disease	Concomitant disease	Past disease	Age	Gestational week	Symptoms	Treatment	Outcome
Ronnje et al[62]	1	HELLP	HT; OO	Appendectomy; cholecystectomy	26	32	Flu-like (myalgia, arthralgia, cough); abdominal pain; fever	CS paracetamol; Morphine; dalteparin 7500 UI/d; betamethasone; cefotaxime	M + B: alive
Mendoza et al[49]	5	PE; HELLP	NR	NR	39.4 (34.2-44.5)	28.6 (22.3-32.4)	Severe pneumonia	1 CS, hypertensive therapy; 4 no delivery	M + B: alive
Rabiei et al[56]	1	IHCP	HT; GDM	Primary infertility	38	29 + 2	Flu-like (myalgia, arthralgia, cough)	UDCA; CS	M and 2nd baby: alive; 1st and 3rd baby: death
Ahmed et al[65]	1	HELLP	NR	NR	26	NR	Confusion; intraabdominal hematoma	Surgery; CS	M + B: Alive
Čivrná et al[61]	2	HELLP; HR	NR	NR	NR	NR	1st flu-like (myalgia, arthralgia, cough); 2nd ARDS, HR	CS	1st M + B: alive; 2nd: NR
Choudhary et al[51]	1	PE; AFLP	NR	NR	27	35	Icteric fever; flu-like (myalgia, arthralgia, cough); renal failure	Labetalol 200 mg/d; Mg sulfate; CS	M + Both babies: alive
Arslan et al[60]	1	HELLP	NR	NR	30	32	Flu-like (myalgia, arthralgia, cough); fever; pneumonia; renal failure; sepsis	CS	M + B: death
D’Ambrosi et al[54]	20	IHCP	NR	NR	30.5 ± 5.7		Flu-like (myalgia, arthralgia, cough); fever	NR	M + B: alive
Futterman et al[68]	2	HELLP	NR	NR	NR	22; 29	NR	NR	1st M + B: death; 2nd M + B: alive

AFLP: Acute fatty liver of pregnancy; ARDS: Acute hypoxemic respiratory failure; B: Baby; CS: Corticosteroids; GDM: Gestational diabetes mellitus; GW: Gestational week; HELLP: Hemolysis, elevated liver enzymes and low platelets; HR: Hepatic rupture; HT: Hypothyroidism; IHCP: Intrahepatic cholestasis of pregnancy; M: Mother; M + B: Mother and baby; Mg: Magnesium; NR: Not reported, OO: Overweight and obese; PE: Preeclampsia; UDCA: Ursodeoxycholic acid.